If someone in your family is a carrier of, or affected by, a severe genetic condition that is different from those in the standard Ashkenazi panels, then it may be advisable to get screened for that disorder. Where a clear family history is identified, the NHS may provide disorder specific screening. Ask your GP to refer you to your local clinical genetics centre to explore if you have access to screening for a disorder known in your family.
If you have a family history of a dominant condition such as Dystonia or, more commonly, breast, ovarian, prostate or pancreatic cancer associated with the BRCA genes, screening for these may also be advisable and available on the NHS. You can ask your GP to refer you to your local genetics service for a discussion with a genetic counsellor. For more information about hereditary cancers, see: www.jnetics.org/jewish_genetic_disorders/hereditary_cancers.